Immunometabolic Reprogramming by Thyroid-Stimulating Antibodies Drives Orbital Adipogenesis via Histone Lactylation in Thyroid Eye Disease
Yanchen Zhang, Neng Ling, Min Wu, Ling Zeng, Ben Chen, Weibin Liu, Zhixing Li, Yan Zhang, Xiaojing Li, Xuanwen Li, YiCheng Mao, Yate Huang, Shiguan Zhou, Shuhui Wan, Hongmei Wang, , Wencan Wu
This paper identifies metabolic reprogramming driven by thyroid-stimulating antibodies as a key mechanism in thyroid eye disease, showing lactate promotes adipogenesis through histone lactylation.
bioRxiv · Jul 30, 2026 · PreprintImmunology