A novel age-informative polygenic score improves predictive ability for kidney function and kidney function decline
Janina M. Herold, Simon Wiegrebe, Barbara Thorand, Thomas W. Winkler, C Gieger, Florian Hartig, M. Behr, Annette Peters, Helmut Küchenhoff, Iris M. Heid
The paper develops an age-informative polygenic score for kidney function and shows it improves prediction of eGFR and decline compared to an age-agnostic score.
medRxiv · Jan 23, 2026 · PreprintGenetic & Genomic Medicine