Association Study of Over 200,000 Subjects Detects Novel Rare Variants, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility
Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, Caroline Gar-Ling Tai, Joel Mefford, Linda Kachuri, Eunice Wan, Simon Wong, David S. Aaronson, Joseph C. Presti, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, , John S. Witte
This study identifies six novel genetic loci, including two rare variants, and shows that a polygenic risk score strongly predicts prostate cancer risk.
Cancer Research · Dec 8, 2020Peer-reviewedGenomics