Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto-Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Khani Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, M. S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa
This study identifies recurrent ERBB4 mutations with oncogenic potential and resistance to targeted therapies, suggesting clinical implications for treatment strategies.
Molecular Oncology · Dec 23, 2025Peer-reviewedCancer Biology