Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.
Madhura Kulkarni, Christopher M. Bourne, Ashutosh B. Mahale, Patrick M. Exconde, Cecelia Murphy, Haley T. Goodrow, Sofia Cervantes, Matilda Kardhashi, Mirai Kambayashi, William Yoo, Tristan J. Wrong, Robert C. Patio, Bohdana M. Discher, Cornelius Y. Taabazuing
This study identifies CASP4/5 as activators of CASP3/7 and GSDME in human macrophages, showing that CASP3 restricts Salmonella replication through apoptosis.
PLoS Pathogens · Apr 27, 2026Peer-reviewedCell Biology