Variational Autoencoder-enabled High-throughput Drug Screening for HIV Latency Modulators predicted through Noise in Gene Expression
Yiyang Lu, Jesse R. Horne, Xuenan Mi, Shivank Nag, Sohom Dash, Roy D. Dar, Diwakar Shukla
This study uses a variational autoencoder to screen ~175,000 compounds for HIV latency modulators, identifying 16 LRAs and 2 LPAs with a 15.9% experimental hit rate.
bioRxiv · Jul 9, 2026 · PreprintBiochemistry