Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC
Sonja Decking, Ines Ugele, Katja Dettmer, Gabriel Horkovics-Kovats, Julian Kuenzel, Charlotte L. Zuur, Joleen Traits, Clarissa Korf, Julian Todt, Fabian Kellermeier, Leah Voelkl, Torunn Zierul, Antonia Hehemann, Florian Westphal, Hanna Wenzel, , Kathrin Renner
This study identifies glutamine metabolism as a key mechanism limiting T cell infiltration and function in HNSCC, showing that targeting glutaminase-1 enhances immune response.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology