A Conformational Switch in the Catalytic Lysine Governs the Stereochemical Outcome of DERA-Catalyzed Aldol Addition
Srita Dutta, Ananya Nayak, Kodru Jeevani, Saravanan Thangavelu, Jagannath Mondal, Anand T. Vaidya
This study identifies a conformational switch in the catalytic lysine of DERA that governs its enantioselectivity, revealing a mechanism for stereochemical outcome in aldol addition.
bioRxiv · Jul 27, 2026 · PreprintBiochemistry