PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling
Paige V. Halas, Hannah Savage, Stephanie J. Hachey, Tatyana Lev, Angela Lincy Prem Antony Samy, Connie C.C. Chan, Stephanie Jimenez, Radhika M Domadia, Iana Lin, Sharmila Mallya, Jacob Insua‐Rodríguez, Jessica Gonzalez, Isam Adam, Hamad S. Alshetaiwi, Grace A. Hernandez, , Devon A. Lawson
This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.
bioRxiv · Aug 19, 2025 · PreprintCancer Biology