Spatial transcriptomics of pediatric tuberculosis lymph nodes reveals a conserved hypoxia_SPP1 niche
S Odunola Adebiyi, Pierre Goussard, Daniel R. De Wet, Jacques T. Janson, Tracey Jooste, Ayanda Shabangu, Anca Dorhoi, Stephen Bondoc, Michael Nekorchuk, Michael C. Chao, Sarah M. Fortune, Kathleen Busman-Sahay, Jacob D. Estes, Elya A. Shamskhou, Kevin B Urdahl, , Nelita Du Plessis
This study uses spatial transcriptomics to identify a hypoxia-associated SPP1-enriched microenvironment in pediatric TB granulomas that may contribute to incomplete bacterial clearance.
bioRxiv · Nov 3, 2026 · PreprintImmunology