A two-membrane gateway for monocarboxylates couples host glycolysis to Toxoplasma mitochondrial fitness and virulence
Melanie Key, Steven Joseph, Zhicheng Dou
This study identifies a two-membrane pathway in Toxoplasma gondii that imports host lactate and pyruvate to sustain mitochondrial function and virulence, revealing host monocarboxylates as critical fuels for parasite survival.
bioRxiv · Feb 24, 2026 · PreprintMicrobiology