Restricted amino acid diversity alters enzymatic phosphoryl-transfer catalysis
Sota Yagi, Subrata Dasgupta, Shusuke Tagami, Satoshi Akanuma
This study shows that restricting amino acid diversity can replace native enzymatic activity with an alternative phosphoryl-transfer reaction in a reconstructed ancestral nucleoside diphosphate kinase.
bioRxiv · Mar 5, 2026 · PreprintEvolutionary Biology