Upregulated GRP78 and sFlt-1 in preeclampsia induces IRE1 and ATF6 arms of UPR leading to ER stress in placental cells
Sankat Mochan, Sunil Kumar Gupta, Pallavi Arora, Neerja Rani, Neerja Bhatla, Sada Nand Dwivedi, Renu Dhingra
The paper investigates the role of upregulated GRP78 and sFlt-1 in preeclampsia, showing their induction of IRE1 and ATF6 arms of UPR and ER stress in placental cells through in vitro experiments.
bioRxiv · May 30, 2023 · PreprintDevelopmental Biology