A duplexed CRISPRi-based approach to predict synergistic antibiotic targets in Escherichia coli.
Xianyi Xiong, Hannah Furseth, Brady McCoy, Lauren Slavic, Xun Feng Yuan, Sydney Chen, Anthony D. Baughn, Yusuke Minato, William R. Harcombe
The paper uses CRISPRi to predict synergistic antibiotic targets in E. coli by testing gene co-repression and identifying novel interactions.
bioRxiv · May 15, 2024 · PreprintMicrobiology