BiochemistrybioRxiv
Covalent inhibition by a natural product-inspired latent electrophile
D. P. Byun, J. Ritchie, R. Holewinski…·E. Yoo
This study evaluates the reactivity and selectivity of 3-bromo-4,5-dihydroxazole electrophiles against human cysteine residues and validates their covalent binding to specific targets.
DOI 10.1021/jacs.3c00598