E. Yoo

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

Covalent inhibition by a natural product-inspired latent electrophile

This study evaluates the reactivity and selectivity of 3-bromo-4,5-dihydroxazole electrophiles against human cysteine residues and validates their covalent binding to specific targets.

Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts

The paper develops fluorescent probes for cancer detection by screening peptide libraries in tissue extracts, identifying highly effective tumor-specific probes that outperform previous designs.

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease

The paper uses peptide substrate libraries to determine the specificity of bacterial Lon protease and develops a potent inhibitor that affects Lon function in E. coli without toxicity to mammalian cells.