Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling
P. Silva, N. Hernandez, H. Tapia, B. Gaete, T. Flores, D. Herrera, A. Caceres, M. Varas, V. A. Torres
This study shows hypoxic tumor cells release extracellular vesicles containing ALS2, which activate Rab5 in endothelial cells to promote angiogenesis via β-catenin stabilization.
bioRxiv · Feb 2, 2024Cell Biology