Neutrophil-extracellular trap-associated RNA (naRNA) and LL37 enable self-amplifying inflammation in psoriasis
F. Herster, Z. Bittner, S. Dickhoefer, D. Eisel, T. Eigenbrod, T. Knorpp, N. Schneiderhan-Marra, M. W. Loeffler, H. Kalbacher, D. Hartl, L. Freund, K. Schaekel, M. Heiser, K. Ghoreschi, A. N. R. Weber
The paper shows RNA-LL37 complexes activate neutrophils via TLR8, leading to cytokine release and NET formation, which may drive self-sustaining inflammation in psoriasis.
bioRxiv · Feb 19, 2019 · PreprintImmunology