The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth
A. Franklin, A. J. Layton, T. Mize, V. C. Salgueiro, R. Sullivan, S. T. Benedict, S. S. Gurcha, I. Anso, G. S. Besra, M. Banzhaf, A. L. Lovering, S. J. Williams, M. E. Guerin, N. E. Scott, R. Prados-Rosales, , P. J. Moynihan
This study identifies LamH, a glycoside hydrolase that cleaves -1,6-mannoside linkages in LAM/LM, enabling their export to the capsule and promoting bacterial growth.
bioRxiv · Oct 26, 2023Microbiology