Targeting the SUMO pathway primes all-trans-retinoic acid-induced differentiation of non promyelocytic Acute Myeloid Leukemias
H. Baik, M. Boulanger, M. Hosseini, J. Kowalczyk, S. Zaghdoudi, T. Salem, J.-E. Sarry, Y. Hicheri, G. Cartron, M. Piechaczyk, g. bossis
This study shows that inhibiting the SUMO pathway enhances the effectiveness of all-trans-retinoic acid in treating non-APL AMLs by promoting differentiation and reducing proliferation.
bioRxiv · Jan 29, 2018Cancer Biology