Polyamines Mediate Folding of Primordial Hyper-Acidic Helical Proteins
D. Despotovic, L. M. Longo, E. Aharon, A. Kahana, T. Scherf, I. Gruic-Sovulj, D. S. Tawfik
This study shows polyamines induce folding of a hyper-acidic ancestral protein, suggesting they may have functioned as chemical chaperones in early life.
bioRxiv · Oct 1, 2020Evolutionary Biology