The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets
M. Okuwaki, S.-i. Ozawa, S. Ebine, M. Juichi, T. Umeki, K. Niioka, T. Kikuchi, N. Tanaka
This study shows that NPM1 oligomer stability, regulated by acidic disordered regions, determines liquid droplet quality through molecular dynamics and mutant analyses.
bioRxiv · Jan 23, 2023Biochemistry