Author

T. V. Seraphim

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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A. O. Tiroli-Cepeda· 1 shared C. H. I. Ramos· 1 shared J. C. Borges· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

A. O. Tiroli-Cepeda

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1 paper

Recent·Most cited

Insights into the effect of the J-domain on the substrate binding domain (SBD) of the 70 kDa heat shock protein, Hsp70, from a chimeric human J-SBD polypeptide

A. O. Tiroli-Cepeda, T. V. Seraphim, J. C. Borges, C. H. I. Ramos

This study investigates the effect of the J-domain on the substrate binding domain of Hsp70 by creating a chimeric J-SBD polypeptide, revealing that J-domain binding shifts Hsp70's equilibrium toward the monomer state, exposing hydrophobic sites for substrate binding.

bioRxiv · Jan 23, 2018Biochemistry