Interaction of HelQ helicase with RPA modulates RPA-DNA binding and stimulates HelQ to unwind DNA through a protein roadblock.
Sarah J. Northall, Tabitha Jenkins, Denis Ptchelkine, Vincenzo Taresco, Christopher D. O. Cooper, Panos Soultanas, Edward L. Bolt
This study identifies HelQ helicase's interaction with RPA, showing it enhances DNA unwinding through protein barriers but not abasic sites by destabilizing RPA-DNA binding.
bioRxiv · Jan 4, 2019 · PreprintBiochemistry