Blockade of Kv3.1 by MK-801, a PCP-Derivative NMDA Receptor Inhibitor: Implications for Models of Schizophrenia
Tae Jun Park, Sang Woong Park, Solah Park, Yeji Lim, Hyeryeong Lee, Jeongbin Kim, Harim Kim, Dong Hyun Kim, Jin O‐Uchi, Mi Seon Seo, Jin Ryeol An, Bok Hee Choi, Young Min Bae
This study shows MK-801 inhibits Kv3.1 channels in CHO cells, with concentration-, voltage-, and use-dependent effects, suggesting a potential mechanism for its role in schizophrenia models.
bioRxiv · Sep 13, 2026 · PreprintPharmacology & Toxicology