Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cells
Yayoi Toyooka, Nami Kawaraichi, Daisuke KAMIYA, Teruyoshi Yamashita, Yusaku Komoike, Kimiko Fukuda, Teppei Akaboshi, Hirokazu Matsumoto, Makoto Ikeya
This study establishes a culture system using Wnt and FGF signaling to expand human iPSC-derived neural crest stem cells long-term, maintaining their self-renewal and differentiation potential.
bioRxiv · Jan 20, 2026 · PreprintDevelopmental Biology