Author

Tess Brunner

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:comparative / phylogenetic analysis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Alexandra M. Clarke· 1 shared Andrew Brantley HalliD· 1 shared Angela K JiangiD· 1 shared Ashley M. SidebottomiD· 1 shared Bhakti Patel· 1 shared Christopher J. LehmanniD· 1 shared Gabriela ArpiD· 1 shared Krysta S. WolfeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Alexandra M. Clarke

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1 paper

Recent·Most cited

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol

Angela K Jiang, Gabriela Arp, Margaret Kato, Tess Brunner, Maggie R. Grant, Alexandra M. Clarke, Ashley M. Sidebottom, Mary McMillin, Christopher J. Lehmann, Matthew August Odenwald, Krysta S. Wolfe, Bhakti Patel, Olatoyosi M. Odenike, Yue Li, Samuel H. Light, , Xiaofang Jiang

The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology