PM2.5 toxin benzopyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling
H. Caohuy, Ognoon Mungunsukh, Tinghua Chen, Qingfeng Yang, Thalia Dib, Bette S. Pollard, Naheed Fatima, Thomas Flagg, Dharmendra Kumar Soni, Roopa Biswas, William Rittase, Oliver J. L’Esperance, Sharon L. Juliano, Harvey B. Pollard
This study shows PM2.5 and its toxin benzo[a]pyrene induce airway inflammation and oxidative stress by up-regulating TRPC6 and inactivating β2AR/CFTR signaling.
bioRxiv · Apr 24, 2026 · PreprintPharmacology & Toxicology