Merkel cell carcinoma-derived macrophage migration inhibitory factor (MIF) may promote persistence of Chronic Lymphocytic Leukemia
Gabriel F. Alencar, Haroldo J. Rodriguez, Thomas H. Pulliam, Allison Jeanne Remington, Macy W. Gilmour, Rian Alam, Austin J. Jabbour, Logan J. Mullen, Blair L. DeBuysscher, Paul Nghiem, Justin J. Taylor
The paper shows that Merkel cell carcinoma produces MIF, which supports CLL persistence through CD74 and CXCR4 activation, explaining why CLL blood counts normalize after MCC treatment.
bioRxiv · Sep 9, 2024 · PreprintCancer Biology