A journey towards developing a new cleavable crosslinker reagent for in-cell crosslinking
Fränze Müller, Bogdan R. Brutiu, Iakovos Saridakis, Thomas Leischner, Micha Johannes Birklbauer, Manuel Matzinger, Mathias Madalinski, Thomas Lendl, Saad Shaaban, Viktoria Dorfer, Nuno Maulide, Karl Mechtler
This paper introduces a new cleavable crosslinker, DiSPASO, for in-cell crosslinking and evaluates its performance in different model systems.
Communications Chemistry · Jun 23, 2025Peer-reviewedBiochemistry