Local conformational plasticity underlies ligand recognition and proton coupling in MFS multidrug transporters
Kyo Coppieters ’t Wallant, Thomas Tilmant, Romain Malempré, Maria Mamkaeva, Loïc Quinton, Cédric Govaerts, Chloé Martens
This study uses HDX-MS to show that local conformational plasticity in MFS transporters enables ligand recognition and proton coupling, revealing dynamic adaptations beyond static structures.
bioRxiv · May 29, 2026 · PreprintBiochemistry