Cotranslational assembly imposes evolutionary constraints on homomeric proteins
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Guilhem Chalancon, Tilman Flock, Jonathan TS Hopper, Balint Kintses, Lejla Daruka, Gergely Fekete, Csaba Pal, Balazs Papp, Peter Horvath, Joseph A Marsh, Adrian H Elcock, M Madan Babu, , Sarah A Teichmann
The paper shows that homomeric proteins tend to have interfaces near the C-terminus, which is favorable for cotranslational assembly and reduces misassembly.
bioRxiv · Sep 13, 2016Cell Biology