LFMD: detecting low-frequency mutations in high-depth genome sequencing data without molecular tags
Rui Ye, Xuehan Zhuang, Jie Ruan, Yanwei Qi, Yitai An, Jiaming Xu, Timothy Mak, Xiao Liu, Xiuqing Zhang, Huanming Yang, Xun Xu, Larry Baum, Chao Nie, Pak Chung Sham
LFMD improves low-frequency mutation detection in high-depth sequencing by combining duplex sequencing and bottleneck sequencing to enhance sensitivity and specificity.
bioRxiv · Nov 18, 2020 · PreprintBioinformatics