Author

Titia Sixma

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Cynthia WolbergeriD· 1 shared David Komander· 1 shared Katerina Growkova· 1 shared Marcello Clerici· 1 shared Marie Morrow· 1 shared Michael Morgan· 1 shared Michal Simicek· 1 shared Ming Yan· 1 shared

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2017-2017 · peak 1/yr

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1 shared paperBiochemistry

Cynthia WolbergerORCID

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1 paper

Recent·Most cited

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

Marie Morrow, Michael Morgan, Marcello Clerici, Katerina Growkova, Ming Yan, David Komander, Michal Simicek, Titia Sixma, Cynthia Wolberger

The paper shows that replacing the catalytic cysteine in DUBs with alanine increases their ubiquitin binding affinity, potentially causing unintended physiological effects.

bioRxiv · Dec 22, 2017 · PreprintBiochemistry