De novo design of small cyclic peptide inhibitors from non-canonical amino acids by cofolding-guided search
Zander Harteveld, Federica Rigoldi, Chiara Toniolo, Alice Granger, Clement Gensous, Torsten Blum, Ronald Jean-Baptiste, Masa Kobayashi, Gregg Siegal, Sevan Habeshian, Lena Tagmose, Oliver Horlacher
This paper introduces nCycle-Forge, a computational method for designing cyclic peptides that outperforms existing approaches in hit rate and potency against two targets.
bioRxiv · Sep 24, 2026 · PreprintBioinformatics