Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα
Richard A. Pepermans, Antonio J. Tenorio, Travis Saxon, Marat R. Talipov, William A. Maio, Chinnasamy Ramesh, Eric R. Prossnitz, Jeffrey B. Arterburn
The paper synthesizes substituted oxabicyclic phenol derivatives with enhanced affinity and activity for ERα, achieving subnanomolar potency comparable to E2.
bioRxiv · Oct 1, 2026 · PreprintPharmacology & Toxicology