p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
Ravi Kumar, Simon Couly, Bruna Rodrigues Muys, Xiao Ling Li, Ioannis Grammatikakis, Ragini Singh, Mary Guest, Xinyu Wen, Wei Tang, Stefan Ambs, Lisa M. Miller Jenkins, Erica C. Pehrsson, Raj Chari, Tsung-Ping Su, Ashish Lal
This study identifies ZMAT3 as a regulator of HKDC1 transcription through JUN, suppressing mitochondrial respiration in colorectal cancer cells.
bioRxiv · May 12, 2025 · PreprintCancer Biology