LILRB3 (ILT5) is a myeloid checkpoint on myeloid cells that elicits profound immununomodulation
M. Yeboah, C. Papagregoriou, D. C. Jones, H. T. C. Chan, G. Hu, J. S. McPartlan, T. Schiott, U. Mattson, C. I. Mockridge, U.-C. Tornberg, B. Hambe, A. Ljungars, M. Mattsson, I. Tews, M. J. Glennie, , A. Roghanian
This study identifies LILRB3 as a myeloid checkpoint receptor that suppresses immune responses through agonistic monoclonal antibodies, showing immunosuppressive effects in vitro and in humanized mice.
bioRxiv · Jun 4, 2020Immunology