Chronically radiation-exposed survivor glioblastoma cells display poor response to Chk1 inhibition
N. Pinarbasi Degirmenci, I. Sur-Erdem, V. Akcay, Y. Bolukbasi, U. Selek, I. Solaroglu, T. Bagci-Onder
This study shows that glioblastoma cells surviving chronic radiation upregulate DNA repair genes and are less sensitive to Chk1 inhibition, especially under hypoxia.
bioRxiv · Apr 16, 2022 · PreprintCancer Biology