Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints
V. Chardes, M. Vergassola, A. M. Walczak, T. Mora
The paper models the trade-off between immune protection and metabolic costs during affinity maturation, predicting power-law distributions of clonotype sizes and antigenic imprinting.
bioRxiv · Jul 26, 2021Immunology