Circulating multimeric immune complexes drive immunopathology in COVID-19
J. Ankerhold, S. Giese, P. Kolb, A. Maul-Pavicic, R. E. Voll, N. Goeppert, K. Ciminski, C. Kreutz, A. Lother, U. Salzer, W. Bildl, T. Welsink, N. Morgenthaler, A. Busse Grawitz, D. Huzly, , V. Falcone
This paper identifies soluble immune complexes as drivers of immunopathology in severe COVID-19 by enhancing FcγRIII activation and forming a vicious cycle of inflammation.
bioRxiv · Jun 25, 2021 · PreprintImmunology