The glycolysis regulator PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma.
M. Sittewelle, V. Kappes, D. Lecuyer, A. H. Monsoro-Burq
This study identifies a novel glycolysis-independent role of PFKFB4 in promoting melanoma cell migration through interaction with ICMT and activation of RAS/AKT signaling.
bioRxiv · Mar 23, 2020 · PreprintCell Biology