Evolution of Gram+ Streptococcus pyogenes has maximized efficiency of the Sortase A cleavage site
B. M. Readnour, Y. A. Ayinuola, B. Russo, Z. Liang, V. A. Fischetti, V. Ploplis, S. W. Lee, F. J. Castellino
This study shows that the Thr4 residue in the SrtA cleavage site of Streptococcus pyogenes M-protein evolved to ensure efficient SrtA cleavage over non-functional cleavage by LPXTGase, stabilizing the virulence factor on the cell wall.
bioRxiv · Dec 21, 2021 · PreprintMicrobiology