Pro-tumor and prothrombotic activities of hepsin in colorectal cancer cells and suppression by venetoclax
M. C. Rodenas, J. Penas-Martinez, I. Pardo-Sanchez, D. Zaragoza Huesca, C. Ortega-Sabater, J. Pena-Garcia, S. Espin, G. Ricote, S. Montenegro, F. Ayala de la Pena, G. Luengo-Gil, A. Nieto, F. Garcia-Molina, V. Vicente, F. Bernardi, , I. Martinez-Martinez
This study shows hepsin promotes tumor aggressiveness and thrombosis in colorectal cancer, and venetoclax inhibits these effects by targeting hepsin.
bioRxiv · Oct 1, 2022 · PreprintCancer Biology