Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from Methylated DNA Sequencing data (MeD-seq)
Daan M. Hazelaar, Ruben Boers, Joachim Boers, Vanja de Weerd, Jean Helmijr, Maurice PHM Jansen, Henk M.W. Verheul, Cornelis Kees Verhoef, Joost H. Gribnau, John W.M. Martens, Stavros Makrodimitris, Saskia M. Wilting
The paper introduces MeD-seq, a method to profile circulating tumor DNA by analyzing DNA methylation and copy number changes, showing its effectiveness in detecting cancer-specific signals in plasma samples.
npj Precision Oncology · Dec 15, 2025Peer-reviewedBioinformatics