Cancer BiologybioRxivPreprint
HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma
Yilong Zou, Michael J. Palte, Amy A. Deik…·Stuart L. Schreiber
This paper identifies a vulnerability in clear-cell renal cell carcinoma cells to ferroptosis induced by GPX4 inhibition, driven by the HIF-2-HILPDA pathway and PUFA-lipid enrichment.
DOI 10.1101/388041