Estrogen is Coupled to the Calcium Release Machinery in HumanLeiomyoma Cells
Ariana Machado, Jasmine Kaur, Veronica Kan, Ying Fan, Mostafa A. Borahay, Darren F. Boehning
This study shows estrogen promotes leiomyoma growth by activating GPR30, which triggers calcium release, and blocking this pathway reduces tumor proliferation.
bioRxiv · Sep 23, 2026 · PreprintCell Biology