VopU is a novel T3SS effector protein with mono-ADP-ribosyltransferase activity and a non-canonical H-Y-Q catalytic triad
Sebastián A. Jerez, Maria J Puentes-Maldonado, Victor Cabrera, Fernando A. Amaya, Linda J. Kenney, Carlos A. Santiviago, Carlos J. Blondel
This paper identifies VopU as a novel T3SS effector with mono-ADP-ribosyltransferase activity using a non-canonical H-Y-Q catalytic triad, showing it induces host cell stress and NAD depletion during infection.
bioRxiv · May 8, 2026 · PreprintMicrobiology