Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation
Andrew P. Longhini, Austin DuBose, Samuel Lobo…·Kenneth S. Kosik
The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.
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