Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma
Christopher Wirth, Tongwu Zhang, Marcos Díaz‐Gay, Christopher D. Steele, Phuc H. Hoang, Yang Yang, Azhar Khandekar, Wei Zhao, Jian Sang, Charles Leduc, Marina K. Baine, W. Travis, Lynette Marie Sholl, Philippe Joubert, Robert Homer, , Maria Teresa Landi
This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.
bioRxiv · Dec 23, 2025 · PreprintCancer Biology